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Treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine has been shown to improve the symptoms of major depressive disorder (MDD) and thereby decrease depression-related distress. Such a reduction in distress presumably leads to an increase in the activity level of the individual. The primary aim of this exploratory study was to test this assumption. A secondary aim was to investigate how a depressive episode might influence the relationship between mood and activity. Activity levels were assessed by means of the GPS-portable tracker system, Actilogger. We found that the activity levels of 20 patients with MDD were significantly increased at a median of 4 days (range 2-9) after initiation of treatment with fluoxetine. Before treatment with fluoxetine, patient activity levels were already at the upper limit of normal activity levels and higher than average population activity levels. However, all patients had activities below their normal activity levels after initiation of fluoxetine. A retrospective analysis of the average duration of depressive episodes showed no association with the change in activity. The results are in line with previous findings, indicating an improvement of the activity of patients with MDD upon initiation of treatment with fluoxetine. Furthermore, our findings suggest that the activity levels of patients with MDD are, to some extent, independent of the duration of the depressive episode.Q:
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